{"id":12107,"date":"2024-11-11T13:39:53","date_gmt":"2024-11-11T10:39:53","guid":{"rendered":"https:\/\/cidsr.md\/?post_type=news&p=12107"},"modified":"2024-11-14T13:49:11","modified_gmt":"2024-11-14T10:49:11","slug":"indukcija-rodov-mifepriston-i-mizoprostol-v-sravnenii-s-monopolicejskim-mizoprostolom-dlja-indukcii-rodov-u-zhenshhin-s-vnutriutrobnoj-smertju-ploda-metaanaliz-i-sistematicheskij-obzor","status":"publish","type":"news","link":"https:\/\/cidsr.md\/ru\/news\/indukcija-rodov-mifepriston-i-mizoprostol-v-sravnenii-s-monopolicejskim-mizoprostolom-dlja-indukcii-rodov-u-zhenshhin-s-vnutriutrobnoj-smertju-ploda-metaanaliz-i-sistematicheskij-obzor\/","title":{"rendered":"\u0418\u041d\u0414\u0423\u041a\u0426\u0418\u042f \u0420\u041e\u0414\u041e\u0412: \u041c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u0441 \u043c\u043e\u043d\u043e\u043f\u043e\u043b\u0438\u0446\u0435\u0439\u0441\u043a\u0438\u043c \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u043e\u043c \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u044c\u044e \u043f\u043b\u043e\u0434\u0430: \u043c\u0435\u0442\u0430\u0430\u043d\u0430\u043b\u0438\u0437 \u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043e\u0431\u0437\u043e\u0440","raw":"\u0418\u041d\u0414\u0423\u041a\u0426\u0418\u042f \u0420\u041e\u0414\u041e\u0412: \u041c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u0441 \u043c\u043e\u043d\u043e\u043f\u043e\u043b\u0438\u0446\u0435\u0439\u0441\u043a\u0438\u043c \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u043e\u043c \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u044c\u044e \u043f\u043b\u043e\u0434\u0430: \u043c\u0435\u0442\u0430\u0430\u043d\u0430\u043b\u0438\u0437 \u0438 \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043e\u0431\u0437\u043e\u0440"},"content":{"rendered":"

\"\"<\/p>\n

\u041c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430. \u0422\u0435\u043c \u043d\u0435 \u043c\u0435\u043d\u0435\u0435, \u043d\u0435\u0434\u0430\u0432\u043d\u0438\u0435 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f (\u0420\u041a\u0418) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u043c\u043e\u0436\u0435\u0442<\/p>\n

\u041a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0432\u044b\u0431\u043e\u0440\u0430<\/p>\n

\u041a\u0440\u0438\u0442\u0435\u0440\u0438\u044f\u043c\u0438 \u043f\u0440\u0438\u0435\u043c\u043b\u0435\u043c\u043e\u0441\u0442\u0438 \u0431\u044b\u043b\u0438: (1) \u0420\u041a\u0418, (2) \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0441 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c, (3) \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043a\u0438, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0435 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u0432\u044f\u0437\u0438 \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0438 (4) \u0441\u043e\u043e\u0431\u0449\u0435\u043d\u0438\u0435 \u043f\u043e \u043a\u0440\u0430\u0439\u043d\u0435\u0439 \u043c\u0435\u0440\u0435 \u043e\u0431 \u043e\u0434\u043d\u043e\u043c \u0440\u0435\u043b\u0435\u0432\u0430\u043d\u0442\u043d\u043e\u043c \u0438\u0441\u0445\u043e\u0434\u0435.<\/p>\n

\u0421\u0431\u043e\u0440 \u0438 \u0430\u043d\u0430\u043b\u0438\u0437 \u0434\u0430\u043d\u043d\u044b\u0445<\/p>\n

\u0414\u0430\u043d\u043d\u044b\u0435 \u0431\u044b\u043b\u0438 \u0438\u0437\u0443\u0447\u0435\u043d\u044b \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043c\u0435\u0442\u043e\u0434\u0430 \u041c\u0430\u043d\u0442\u0435\u043b\u0430\u2013\u0425\u0435\u043d\u0437\u0435\u043b\u044f \u0438 95% \u0414\u0418. \u0413\u0435\u0442\u0435\u0440\u043e\u0433\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043e\u0446\u0435\u043d\u0438\u0432\u0430\u043b\u0438 \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u0441\u0442\u0430\u0442\u0438\u043a\u0438 I2. \u0414\u043b\u044f \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043b\u0430\u0441\u044c \u0432\u0435\u0440\u0441\u0438\u044f R 4.2.3. \u0410\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043b\u0438\u0441\u044c \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0435 \u0438\u0441\u0445\u043e\u0434\u044b: \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b \u0440\u043e\u0434\u043e\u0432, \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u044b (\u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0430, \u0440\u0432\u043e\u0442\u0430, \u0434\u0438\u0430\u0440\u0435\u044f \u0438 \u0442\u043e\u0448\u043d\u043e\u0442\u0430) \u0438 \u043e\u0446\u0435\u043d\u043a\u0430 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u043f\u0435\u0440\u0435\u0434 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0435\u0439. \u0414\u0440\u0443\u0433\u0438\u0435 \u0432\u0430\u0436\u043d\u044b\u0435 \u0438\u0441\u0445\u043e\u0434\u044b, \u0442\u0430\u043a\u0438\u0435 \u043a\u0430\u043a \u0440\u0430\u0437\u0440\u044b\u0432 \u043c\u0430\u0442\u043a\u0438, \u043d\u0435 \u043c\u043e\u0433\u043b\u0438 \u0431\u044b\u0442\u044c \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u044b \u0438\u0437-\u0437\u0430 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u044f \u0434\u0430\u043d\u043d\u044b\u0445 \u0438\u0437 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439.<\/p>\n

\u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b<\/p>\n

\u0412 \u043e\u0431\u0449\u0435\u0439 \u0441\u043b\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0441\u0435\u043c\u044c \u0420\u041a\u0418, \u0432 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043f\u0440\u0438\u043d\u044f\u043b\u0438 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 599 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0431\u044b\u043b\u0438 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u0432 \u0433\u0440\u0443\u043f\u043f\u0443 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0438\u043b\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0434\u043b\u044f \u0441\u0442\u0438\u043c\u0443\u043b\u044f\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432. \u041f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0433\u0440\u0443\u043f\u043f\u043e\u0439, \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0432\u0448\u0435\u0439 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b, \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u043c\u0435\u043b\u043e \u043c\u0435\u043d\u044c\u0448\u0438\u0439 \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b (\u0420\u0421 \u20136,86 \u0447; 95% \u0414\u0418: \u043e\u0442 \u221210,32 \u0434\u043e \u22123,4; \u0420 = 0,0001; I2 = 87%). \u041e\u0434\u043d\u0430\u043a\u043e, \u0441 \u0442\u043e\u0447\u043a\u0438 \u0437\u0440\u0435\u043d\u0438\u044f \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0445 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432, \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u0430\u0441\u044c \u0431\u043e\u043b\u0435\u0435 \u043d\u0438\u0437\u043a\u0430\u044f \u0447\u0430\u0441\u0442\u043e\u0442\u0430 \u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0438 (2,25% \u043f\u0440\u043e\u0442\u0438\u0432 12,12%; \u0420\u0420 0,26; 95% \u0414\u0418: 0,09\u20130,74; \u0420 = 0,01; I2 = 0%) \u0438 \u0440\u0432\u043e\u0442\u0430 (7,64% \u043f\u0440\u043e\u0442\u0438\u0432 14,45%; \u0420\u0420 0,54; 95% \u0414\u0418: 0,29\u20131,01; \u0420 = 0,05; I2 = 0%). \u0421\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u0445 \u0440\u0430\u0437\u043b\u0438\u0447\u0438\u0439 \u043f\u0440\u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u043f\u0440\u0435\u0434\u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u043e\u0446\u0435\u043d\u043a\u0438 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u0432 \u0434\u0432\u0443\u0445 \u0433\u0440\u0443\u043f\u043f\u0430\u0445 \u043d\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u043e\u0441\u044c (\u0420\u0421 \u20130,09; 95% \u0414\u0418: \u20130,28\u20130,10; \u0420 = 0,35; I2 = 0%). \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0441\u0440\u0435\u0434\u043d\u0435\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0435\u0434\u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e \u0431\u0430\u043b\u043b\u0430 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u043f\u0440\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u043e 2 \u043f\u0440\u043e\u0442\u0438\u0432 2,1 \u0432 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044c\u043d\u043e\u0439 \u0433\u0440\u0443\u043f\u043f\u0435.<\/p>\n

\u0417\u0430\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435<\/p>\n

\u0412 \u044d\u0442\u043e\u043c \u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u043e\u043c \u043c\u0435\u0442\u0430\u0430\u043d\u0430\u043b\u0438\u0437\u0435 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u044e\u0442 \u043e \u0442\u043e\u043c, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u0431\u043e\u043b\u0435\u0435 \u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u044b\u043c\u0438 \u0438\u0441\u0445\u043e\u0434\u0430\u043c\u0438, \u0447\u0435\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u043e\u043c \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0445 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u043f\u0440\u0438 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430.<\/p>\n

\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a: https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview<\/a><\/p>\n","protected":false,"raw":"\"\"\r\n\r\n\u041c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430. \u0422\u0435\u043c \u043d\u0435 \u043c\u0435\u043d\u0435\u0435, \u043d\u0435\u0434\u0430\u0432\u043d\u0438\u0435 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f (\u0420\u041a\u0418) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u043c\u043e\u0436\u0435\u0442\r\n\r\n\u041a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0432\u044b\u0431\u043e\u0440\u0430\r\n\r\n\u041a\u0440\u0438\u0442\u0435\u0440\u0438\u044f\u043c\u0438 \u043f\u0440\u0438\u0435\u043c\u043b\u0435\u043c\u043e\u0441\u0442\u0438 \u0431\u044b\u043b\u0438: (1) \u0420\u041a\u0418, (2) \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0441 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c, (3) \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043a\u0438, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0435 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u0432\u044f\u0437\u0438 \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0438 (4) \u0441\u043e\u043e\u0431\u0449\u0435\u043d\u0438\u0435 \u043f\u043e \u043a\u0440\u0430\u0439\u043d\u0435\u0439 \u043c\u0435\u0440\u0435 \u043e\u0431 \u043e\u0434\u043d\u043e\u043c \u0440\u0435\u043b\u0435\u0432\u0430\u043d\u0442\u043d\u043e\u043c \u0438\u0441\u0445\u043e\u0434\u0435.\r\n\r\n\u0421\u0431\u043e\u0440 \u0438 \u0430\u043d\u0430\u043b\u0438\u0437 \u0434\u0430\u043d\u043d\u044b\u0445\r\n\r\n\u0414\u0430\u043d\u043d\u044b\u0435 \u0431\u044b\u043b\u0438 \u0438\u0437\u0443\u0447\u0435\u043d\u044b \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043c\u0435\u0442\u043e\u0434\u0430 \u041c\u0430\u043d\u0442\u0435\u043b\u0430\u2013\u0425\u0435\u043d\u0437\u0435\u043b\u044f \u0438 95% \u0414\u0418. \u0413\u0435\u0442\u0435\u0440\u043e\u0433\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043e\u0446\u0435\u043d\u0438\u0432\u0430\u043b\u0438 \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u0441\u0442\u0430\u0442\u0438\u043a\u0438 I2. \u0414\u043b\u044f \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043b\u0430\u0441\u044c \u0432\u0435\u0440\u0441\u0438\u044f R 4.2.3. \u0410\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043b\u0438\u0441\u044c \u0441\u043b\u0435\u0434\u0443\u044e\u0449\u0438\u0435 \u0438\u0441\u0445\u043e\u0434\u044b: \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b \u0440\u043e\u0434\u043e\u0432, \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u044b (\u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0430, \u0440\u0432\u043e\u0442\u0430, \u0434\u0438\u0430\u0440\u0435\u044f \u0438 \u0442\u043e\u0448\u043d\u043e\u0442\u0430) \u0438 \u043e\u0446\u0435\u043d\u043a\u0430 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u043f\u0435\u0440\u0435\u0434 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0435\u0439. \u0414\u0440\u0443\u0433\u0438\u0435 \u0432\u0430\u0436\u043d\u044b\u0435 \u0438\u0441\u0445\u043e\u0434\u044b, \u0442\u0430\u043a\u0438\u0435 \u043a\u0430\u043a \u0440\u0430\u0437\u0440\u044b\u0432 \u043c\u0430\u0442\u043a\u0438, \u043d\u0435 \u043c\u043e\u0433\u043b\u0438 \u0431\u044b\u0442\u044c \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u044b \u0438\u0437-\u0437\u0430 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u044f \u0434\u0430\u043d\u043d\u044b\u0445 \u0438\u0437 \u0432\u043a\u043b\u044e\u0447\u0435\u043d\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439.\r\n\r\n\u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b\r\n\r\n\u0412 \u043e\u0431\u0449\u0435\u0439 \u0441\u043b\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0441\u0435\u043c\u044c \u0420\u041a\u0418, \u0432 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u043f\u0440\u0438\u043d\u044f\u043b\u0438 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 599 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0431\u044b\u043b\u0438 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u0432 \u0433\u0440\u0443\u043f\u043f\u0443 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0438\u043b\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0434\u043b\u044f \u0441\u0442\u0438\u043c\u0443\u043b\u044f\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432. \u041f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0433\u0440\u0443\u043f\u043f\u043e\u0439, \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0432\u0448\u0435\u0439 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b, \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u043c\u0435\u043b\u043e \u043c\u0435\u043d\u044c\u0448\u0438\u0439 \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b (\u0420\u0421 \u20136,86 \u0447; 95% \u0414\u0418: \u043e\u0442 \u221210,32 \u0434\u043e \u22123,4; \u0420 = 0,0001; I2 = 87%). \u041e\u0434\u043d\u0430\u043a\u043e, \u0441 \u0442\u043e\u0447\u043a\u0438 \u0437\u0440\u0435\u043d\u0438\u044f \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0445 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432, \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u0430\u0441\u044c \u0431\u043e\u043b\u0435\u0435 \u043d\u0438\u0437\u043a\u0430\u044f \u0447\u0430\u0441\u0442\u043e\u0442\u0430 \u043b\u0438\u0445\u043e\u0440\u0430\u0434\u043a\u0438 (2,25% \u043f\u0440\u043e\u0442\u0438\u0432 12,12%; \u0420\u0420 0,26; 95% \u0414\u0418: 0,09\u20130,74; \u0420 = 0,01; I2 = 0%) \u0438 \u0440\u0432\u043e\u0442\u0430 (7,64% \u043f\u0440\u043e\u0442\u0438\u0432 14,45%; \u0420\u0420 0,54; 95% \u0414\u0418: 0,29\u20131,01; \u0420 = 0,05; I2 = 0%). \u0421\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438 \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u0445 \u0440\u0430\u0437\u043b\u0438\u0447\u0438\u0439 \u043f\u0440\u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u043f\u0440\u0435\u0434\u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u043e\u0446\u0435\u043d\u043a\u0438 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u0432 \u0434\u0432\u0443\u0445 \u0433\u0440\u0443\u043f\u043f\u0430\u0445 \u043d\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u043b\u043e\u0441\u044c (\u0420\u0421 \u20130,09; 95% \u0414\u0418: \u20130,28\u20130,10; \u0420 = 0,35; I2 = 0%). \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0441\u0440\u0435\u0434\u043d\u0435\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u043f\u0440\u0435\u0434\u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e \u0431\u0430\u043b\u043b\u0430 \u043f\u043e \u0448\u043a\u0430\u043b\u0435 \u0411\u0438\u0448\u043e\u043f\u0430 \u043f\u0440\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u043e 2 \u043f\u0440\u043e\u0442\u0438\u0432 2,1 \u0432 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044c\u043d\u043e\u0439 \u0433\u0440\u0443\u043f\u043f\u0435.\r\n\r\n\u0417\u0430\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435\r\n\r\n\u0412 \u044d\u0442\u043e\u043c \u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u043e\u043c \u043c\u0435\u0442\u0430\u0430\u043d\u0430\u043b\u0438\u0437\u0435 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u044e\u0442 \u043e \u0442\u043e\u043c, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u0431\u043e\u043b\u0435\u0435 \u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u044b\u043c\u0438 \u0438\u0441\u0445\u043e\u0434\u0430\u043c\u0438, \u0447\u0435\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u043e\u043c \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0445 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u043f\u0440\u0438 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430.\r\n\r\n\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a: https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview<\/a>"},"excerpt":{"rendered":"","protected":false,"raw":""},"author":7,"featured_media":0,"parent":0,"template":"page-news-details.php","blog_news":[111],"class_list":["post-12107","news","type-news","status-publish","hentry","blog_news-publications_cat"],"acf":[],"yoast_head":"\nMifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/\" \/>\n<meta property=\"og:locale\" content=\"ru_RU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive\" \/>\n<meta property=\"og:description\" content=\"\u041c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430. \u0422\u0435\u043c \u043d\u0435 \u043c\u0435\u043d\u0435\u0435, \u043d\u0435\u0434\u0430\u0432\u043d\u0438\u0435 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f (\u0420\u041a\u0418) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u043c\u043e\u0436\u0435\u0442 \u041a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0432\u044b\u0431\u043e\u0440\u0430 \u041a\u0440\u0438\u0442\u0435\u0440\u0438\u044f\u043c\u0438 \u043f\u0440\u0438\u0435\u043c\u043b\u0435\u043c\u043e\u0441\u0442\u0438 \u0431\u044b\u043b\u0438: (1) \u0420\u041a\u0418, (2) \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0441 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c, (3) \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043a\u0438, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0435 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u0432\u044f\u0437\u0438 \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0438 (4) \u0441\u043e\u043e\u0431\u0449\u0435\u043d\u0438\u0435 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/\" \/>\n<meta property=\"og:site_name\" content=\"Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-14T10:49:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cidsr.md\/wp-content\/uploads\/2024\/11\/mifepristona-si-misoprostol-versus-misoprostol.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u041f\u0440\u0438\u043c\u0435\u0440\u043d\u043e\u0435 \u0432\u0440\u0435\u043c\u044f \u0434\u043b\u044f \u0447\u0442\u0435\u043d\u0438\u044f\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 \u043c\u0438\u043d\u0443\u0442\u044b\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/\",\"url\":\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/\",\"name\":\"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive\",\"isPartOf\":{\"@id\":\"https:\/\/cidsr.md\/#website\"},\"datePublished\":\"2024-11-11T10:39:53+00:00\",\"dateModified\":\"2024-11-14T10:49:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/#breadcrumb\"},\"inLanguage\":\"ru-RU\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0413\u043b\u0430\u0432\u043d\u0430\u044f \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430\",\"item\":\"https:\/\/new.cidsr.md\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cidsr.md\/#website\",\"url\":\"https:\/\/cidsr.md\/\",\"name\":\"Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive\",\"description\":\"Promov\u0103m s\u0103n\u0103tatea \u0219i drepturile sexuale \u0219i reproductive!\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cidsr.md\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"ru-RU\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/","og_locale":"ru_RU","og_type":"article","og_title":"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive","og_description":"\u041c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u0443\u0435\u0442\u0441\u044f \u0434\u043b\u044f \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u0438 \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u043b\u0443\u0447\u0430\u044f\u0445 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0441\u043c\u0435\u0440\u0442\u0438 \u043f\u043b\u043e\u0434\u0430. \u0422\u0435\u043c \u043d\u0435 \u043c\u0435\u043d\u0435\u0435, \u043d\u0435\u0434\u0430\u0432\u043d\u0438\u0435 \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u043f\u044b\u0442\u0430\u043d\u0438\u044f (\u0420\u041a\u0418) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u043c\u043e\u0436\u0435\u0442 \u041a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 \u0432\u044b\u0431\u043e\u0440\u0430 \u041a\u0440\u0438\u0442\u0435\u0440\u0438\u044f\u043c\u0438 \u043f\u0440\u0438\u0435\u043c\u043b\u0435\u043c\u043e\u0441\u0442\u0438 \u0431\u044b\u043b\u0438: (1) \u0420\u041a\u0418, (2) \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0441 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c, (3) \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043a\u0438, \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0448\u0438\u0435 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044e \u0440\u043e\u0434\u043e\u0432 \u0432 \u0441\u0432\u044f\u0437\u0438 \u0441 \u0432\u043d\u0443\u0442\u0440\u0438\u0443\u0442\u0440\u043e\u0431\u043d\u043e\u0439 \u0433\u0438\u0431\u0435\u043b\u044c\u044e \u043f\u043b\u043e\u0434\u0430, \u0438 (4) \u0441\u043e\u043e\u0431\u0449\u0435\u043d\u0438\u0435 […]","og_url":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/","og_site_name":"Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive","article_modified_time":"2024-11-14T10:49:11+00:00","og_image":[{"url":"https:\/\/cidsr.md\/wp-content\/uploads\/2024\/11\/mifepristona-si-misoprostol-versus-misoprostol.png"}],"twitter_card":"summary_large_image","twitter_misc":{"\u041f\u0440\u0438\u043c\u0435\u0440\u043d\u043e\u0435 \u0432\u0440\u0435\u043c\u044f \u0434\u043b\u044f \u0447\u0442\u0435\u043d\u0438\u044f":"2 \u043c\u0438\u043d\u0443\u0442\u044b"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/","url":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/","name":"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive","isPartOf":{"@id":"https:\/\/cidsr.md\/#website"},"datePublished":"2024-11-11T10:39:53+00:00","dateModified":"2024-11-14T10:49:11+00:00","breadcrumb":{"@id":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/#breadcrumb"},"inLanguage":"ru-RU","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cidsr.md\/news\/mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u0413\u043b\u0430\u0432\u043d\u0430\u044f \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430","item":"https:\/\/new.cidsr.md\/"},{"@type":"ListItem","position":2,"name":"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103"}]},{"@type":"WebSite","@id":"https:\/\/cidsr.md\/#website","url":"https:\/\/cidsr.md\/","name":"Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive","description":"Promov\u0103m s\u0103n\u0103tatea \u0219i drepturile sexuale \u0219i reproductive!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cidsr.md\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ru-RU"}]}},"meta":{"_en_post_content":"<img class=\"wp-image-12108 alignright\" src=\"https:\/\/cidsr.md\/wp-content\/uploads\/2024\/11\/mifepristona-si-misoprostol-versus-misoprostol.png\" alt=\"\" width=\"517\" height=\"417\" \/>\r\n\r\nMisoprostol is largely used in labor induction in cases of intrauterine fetal death. However, recent randomized clinical trials (RCTs) showed that the combination of mifepristone and misoprostol might\r\n\r\nSelection Criteria\r\n\r\nThe eligibility criteria were (1) RCT, (2) comparing misoprostol alone versus the combined treatment, (3) patients undergoing labor induction due to intrauterine fetal death and (4) reporting at least one relevant outcome.\r\n\r\nData Collection and Analysis\r\n\r\nData were examined using the Mantel\u2013Haenszel method and 95% CIs. Heterogeneity was assessed using I2 statics. R, version 4.2.3 was used for statistical analysis. The analyzed outcomes were delivery time interval, adverse effects (fever, vomiting, diarrhea and nausea) and the preinduction Bishop score. Other important outcomes, such as uterus rupture, could not be included due to lack of data from the included studies.\r\n\r\nMain Results\r\n\r\nA total of seven RCTs comprising 599 patients with intrauterine fetal death were randomized to misoprostol or combined treatment to induce labor. Compared to the misoprostol only group, combined treatment presented lower delivery time interval (MD \u20136.86\u2009h; 95% CI: \u221210.32 to \u22123.4; P\u2009=\u20090.0001; I2\u2009=\u200987%). However, in terms of adverse effects, the combined treatment group presented lower occurrence of fever (2.25% vs 12.12%; RR 0.26; 95% CI: 0.09\u20130.74; P\u2009=\u20090.01; I2\u2009=\u20090%) and vomiting (7.64% vs 14.45%; RR 0.54; 95% CI: 0.29\u20131.01; P\u2009=\u20090.05; I2\u2009=\u20090%). No statistically significant differences were observed when comparing the preinduction Bishop score of the two groups (MD \u20130.09; 95% CI: \u22120.28\u20130.10; P\u2009=\u20090.35; I2\u2009=\u20090%). Additionally, the mean of the preinduction Bishop score of the combined treatment was 2 versus 2.1 of the control group.\r\n\r\nConclusion\r\n\r\nIn this updated meta-analysis, consistent results suggest that the combined treatment is associated with more beneficial outcomes than the misoprostol alone treatment in patients undergoing labor induction in intrauterine fetal death.\r\n\r\nSource: <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview\">https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview<\/a>","_en_post_excerpt":"","_en_post_title":"INDUCTION OF LABOUR: Mifepristone and misoprostol versus misoprostol alone for induction of labour in women with intrauterine fetal death: a meta\u2010analysis and systematic review","_en_post_name":"induction-of-labour-mifepristone-and-misoprostol-versus-misoprostol-alone-for-induction-of-labour-in-women-with-intrauterine-fetal-death-a-meta-analysis-and-systematic-review","_ro_post_content":"<img class=\"wp-image-12108 alignright\" src=\"https:\/\/cidsr.md\/wp-content\/uploads\/2024\/11\/mifepristona-si-misoprostol-versus-misoprostol.png\" alt=\"\" width=\"516\" height=\"416\" \/>\r\n\r\nMisoprostolul este utilizat pe scar\u0103 larg\u0103 \u00een inducerea travaliului \u00een cazurile de moarte fetal\u0103 intrauterin\u0103. Cu toate acestea, studii clinice randomizate recente (RCT) au ar\u0103tat c\u0103 combina\u021bia de mifepriston\u0103 \u0219i misoprostol ar putea avea efecte mai bune dec\u00e2t utilizarea misoprostolului singur.\r\n\r\nCriterii de selec\u021bie\r\n\r\nCriteriile de eligibilitate au fost (1) RCT, (2) compararea misoprostolului singur cu tratamentul combinat, (3) pacien\u021bii supu\u0219i inducerii travaliului din cauza decesului fetal intrauterin \u0219i (4) raportarea a cel pu\u021bin unui rezultat relevant.\r\n\r\nColectarea \u0219i analiza datelor\r\n\r\nDatele au fost examinate folosind metoda Mantel-Haenszel \u0219i CIs 95%. Eterogenitatea a fost evaluat\u0103 folosind statica I2. R, versiunea 4.2.3 a fost utilizat\u0103 pentru analiza statistic\u0103. Rezultatele analizate au fost intervalul de timp al na\u0219terii, efectele adverse (febr\u0103, v\u0103rs\u0103turi, diaree \u0219i grea\u021b\u0103) \u0219i scorul Bishop de preinduc\u021bie. Alte rezultate importante, cum ar fi ruptura uterului, nu au putut fi incluse din cauza lipsei de date din studiile incluse.\r\n\r\nPrincipalele rezultate\r\n\r\nUn total de \u0219apte RCT-uri care cuprind 599 de pacien\u021bi cu deces fetal intrauterin au fost randomiza\u021bi la misoprostol sau tratament combinat pentru a induce travaliul. Comparativ cu grupul cu misoprostol, tratamentul combinat a prezentat un interval de timp mai mic al na\u0219terii (DM -6,86 h; I\u00ce 95%: -10,32 p\u00e2n\u0103 la -3,4; P = 0,0001; I2 = 87%). Cu toate acestea, \u00een ceea ce prive\u0219te efectele adverse, grupul de tratament combinat a prezentat o apari\u021bie mai mic\u0103 a febrei (2,25% fa\u021b\u0103 de 12,12%; RR 0,26; I\u00ce 95%: 0,09-0,74; P = 0,01; I2 = 0%) \u0219i v\u0103rs\u0103turi (7,64% fa\u021b\u0103 de 14,45%; RR 0,54; I\u00ce 95%: 0,29-1,01; P = 0,05; I2 = 0%). Nu au fost observate diferen\u021be semnificative statistic atunci c\u00e2nd s-a comparat scorul Bishop preinduc\u021bie al celor dou\u0103 grupuri (DM -0,09; I\u00ce 95%: -0,28-0,10; P = 0,35; I2 = 0%). \u00cen plus, media scorului Bishop de preinduc\u021bie al tratamentului combinat a fost de 2 fa\u021b\u0103 de 2,1 din grupul de control.\r\n\r\nConcluzie\r\n\r\n\u00cen aceast\u0103 meta-analiz\u0103 actualizat\u0103, rezultatele consistente sugereaz\u0103 c\u0103 tratamentul combinat este asociat cu rezultate mai benefice dec\u00e2t tratamentul cu misoprostol singur la pacien\u021bii supu\u0219i inducerii travaliului \u00een moartea fetal\u0103 intrauterin\u0103.\r\n\r\nSursa: <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview\">https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijgo.15963?campaign=wolearlyview<\/a>","_ro_post_excerpt":"","_ro_post_title":"Mifepriston\u0103 \u0219i misoprostol versus misoprostol ca metod\u0103 singur\u0103 pentru inducerea travaliului la femeile cu deces fetal intrauterin: o meta-analiz\u0103 \u0219i o revizuire sistematic\u0103","_ro_post_name":"mifepristona-si-misoprostol-versus-misoprostol-ca-metoda-singura-pentru-inducerea-travaliului-la-femeile-cu-deces-fetal-intrauterin-o-meta-analiza-si-o-revizuire-sistematica","edit_language":"ru"},"_links":{"self":[{"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/news\/12107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/types\/news"}],"author":[{"embeddable":true,"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/users\/7"}],"wp:attachment":[{"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/media?parent=12107"}],"wp:term":[{"taxonomy":"blog_news","embeddable":true,"href":"https:\/\/cidsr.md\/ru\/wp-json\/wp\/v2\/blog_news?post=12107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}