{"id":10715,"date":"2023-09-01T12:28:59","date_gmt":"2023-09-01T10:28:59","guid":{"rendered":"https:\/\/cidsr.md\/?post_type=news&#038;p=7845"},"modified":"2023-12-08T18:12:08","modified_gmt":"2023-12-08T15:12:08","slug":"eficacitatea-si-siguranta-utilizarii-doar-a-misoprostolului-pentru-avortul-medical-din-primul-trimestru-o-revizuire-sistematica-si-o-meta-analiza-actualizata","status":"publish","type":"news","link":"https:\/\/cidsr.md\/en\/news\/eficacitatea-si-siguranta-utilizarii-doar-a-misoprostolului-pentru-avortul-medical-din-primul-trimestru-o-revizuire-sistematica-si-o-meta-analiza-actualizata\/","title":{"rendered":"Effectiveness and Safety of Misoprostol-Only for First-Trimester Medication Abortion:An Updated Systematic Review and Meta-Analysis[:]","raw":"Effectiveness and Safety of Misoprostol-Only for First-Trimester Medication Abortion:An Updated Systematic Review and Meta-Analysis[:]"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/cidsr.md\/wp-content\/uploads\/2023\/09\/woman-pill-1024x683.jpg\" alt=\"\" width=\"900\" height=\"600\" class=\"aligncenter size-large wp-image-7846\" \/>The evidence establishing the high effectiveness and safety of a regimen combining mifepristone and misoprostol for first-trimester medication abortion is extensive and robust and the use of these two medicines for this purpose has expanded greatly over the past few decades. However, for many people seeking abortion, mifepristone is not always available or accessible. In the absence of mifepristone, use of misoprostol alone is a recommended treatment option.<\/p>\n<p>Gynuity Health Projects conducted a systematic review and meta-analysis of available data on the effectiveness and safety of misoprostol-only for medication abortion in the first 12 weeks of gestation. This latest study updates our <span><a href=\"https:\/\/gynuity.org\/resources\/efficacy-of-misoprostol-alone-for-first-trimester-medical-abortion-a-systematic-review\">prior review<\/a><\/span> published in 2019.<\/p>\n<p><strong>Key Findings<\/strong><\/p>\n<ul>\n<li>Data were collected and analyzed from 49 published papers. A total of 66 trial groups of patients treated with various misoprostol-only regimens were recorded.<\/li>\n<li>Abortion outcomes were established for 16,354 people\u201493% of the total treated population.<\/li>\n<li>Overall, 2,960 individuals experienced treatment failure (meta-analytic estimate: 15%).<\/li>\n<li>Some 521 ongoing pregnancies were recorded in the 9,228 patients assessed for that condition (meta-analytic estimate: 6%).<\/li>\n<li>Among 11,007 patients allowed to take at least three misoprostol doses, the first consisting of misoprostol 800 mcg administered vaginally, sublingually, or buccally, the meta-analytic estimate of the failure risk was 11%.<\/li>\n<li>Very few people were hospitalized for abortion-related reasons or received transfusions\u2014at most 0.2% of the 15,679 evaluable patients.<\/li>\n<\/ul>\n<p>This updated review and analysis shows that most individuals had complete abortion without a procedure or medications beyond the planned misoprostol regimen. It continues to support the key conclusion from our previous study that misoprostol-only is effective and safe for early medication abortion and is a reasonable alternative if obtaining mifepristone is not feasible.<\/p>\n<ol>\n<li>Raymond et al., <a href=\"https:\/\/gynuity.org\/resources\/effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Effectiveness and Safety of Misoprostol-Only for First-Trimester Medication Abortion: An Updated Systematic Review and Meta-Analysis, Contraception,<\/a><\/li>\n<\/ol>\n<p>Digital Object Identifier: <span><a href=\"https:\/\/www.contraceptionjournal.org\/article\/S0010-7824(23)00226-3\/fulltext\">10.1016\/j.contraception.2023.110132<\/a><\/span><\/p>\n<p>Note Medication abortion with mifepristone and misoprostol has indisputable advantages over using misoprostol only and is generally recognized as more efficacious. Policymakers should advocate for greater access to mifepristone.<\/p>\n<p><span><a href=\"https:\/\/gynuity.org\/resources\/research-summary-effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Source:LINK<\/a><\/span><\/p>\n[:]\n<p>&nbsp;[:]\n","protected":false,"raw":"\n\n<img src=\"https:\/\/cidsr.md\/wp-content\/uploads\/2023\/09\/woman-pill-1024x683.jpg\" alt=\"\" width=\"900\" height=\"600\" class=\"aligncenter size-large wp-image-7846\" \/>The evidence establishing the high effectiveness and safety of a regimen combining mifepristone and misoprostol for first-trimester medication abortion is extensive and robust and the use of these two medicines for this purpose has expanded greatly over the past few decades. However, for many people seeking abortion, mifepristone is not always available or accessible. In the absence of mifepristone, use of misoprostol alone is a recommended treatment option.\n\nGynuity Health Projects conducted a systematic review and meta-analysis of available data on the effectiveness and safety of misoprostol-only for medication abortion in the first 12 weeks of gestation. This latest study updates our <span><a href=\"https:\/\/gynuity.org\/resources\/efficacy-of-misoprostol-alone-for-first-trimester-medical-abortion-a-systematic-review\">prior review<\/a><\/span> published in 2019.\n\n<strong>Key Findings<\/strong>\n<ul>\n \t<li>Data were collected and analyzed from 49 published papers. A total of 66 trial groups of patients treated with various misoprostol-only regimens were recorded.<\/li>\n \t<li>Abortion outcomes were established for 16,354 people\u201493% of the total treated population.<\/li>\n \t<li>Overall, 2,960 individuals experienced treatment failure (meta-analytic estimate: 15%).<\/li>\n \t<li>Some 521 ongoing pregnancies were recorded in the 9,228 patients assessed for that condition (meta-analytic estimate: 6%).<\/li>\n \t<li>Among 11,007 patients allowed to take at least three misoprostol doses, the first consisting of misoprostol 800 mcg administered vaginally, sublingually, or buccally, the meta-analytic estimate of the failure risk was 11%.<\/li>\n \t<li>Very few people were hospitalized for abortion-related reasons or received transfusions\u2014at most 0.2% of the 15,679 evaluable patients.<\/li>\n<\/ul>\nThis updated review and analysis shows that most individuals had complete abortion without a procedure or medications beyond the planned misoprostol regimen. It continues to support the key conclusion from our previous study that misoprostol-only is effective and safe for early medication abortion and is a reasonable alternative if obtaining mifepristone is not feasible.\n<ol>\n \t<li>Raymond et al., <a href=\"https:\/\/gynuity.org\/resources\/effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Effectiveness and Safety of Misoprostol-Only for First-Trimester Medication Abortion: An Updated Systematic Review and Meta-Analysis, Contraception,<\/a><\/li>\n<\/ol>\nDigital Object Identifier: <span><a href=\"https:\/\/www.contraceptionjournal.org\/article\/S0010-7824(23)00226-3\/fulltext\">10.1016\/j.contraception.2023.110132<\/a><\/span>\n\nNote Medication abortion with mifepristone and misoprostol has indisputable advantages over using misoprostol only and is generally recognized as more efficacious. Policymakers should advocate for greater access to mifepristone.\n\n<span><a href=\"https:\/\/gynuity.org\/resources\/research-summary-effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Source:LINK<\/a><\/span>\n\n[:]\n\n&nbsp;[:]"},"excerpt":{"rendered":"","protected":false,"raw":""},"author":4,"featured_media":7846,"parent":0,"template":"page-news-details.php","blog_news":[],"class_list":["post-10715","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Eficacitatea \u0219i siguran\u021ba utiliz\u0103rii doar a misoprostolului pentru avortul medical din primul trimestru: o revizuire sistematic\u0103 \u0219i o meta-analiz\u0103 actualizat\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cidsr.md\/%news-slug%\/eficacitatea-si-siguranta-utilizarii-doar-a-misoprostolului-pentru-avortul-medical-din-primul-trimestru-o-revizuire-sistematica-si-o-meta-analiza-actualizata\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Eficacitatea \u0219i siguran\u021ba utiliz\u0103rii doar a misoprostolului pentru avortul medical din primul trimestru: o revizuire sistematic\u0103 \u0219i o meta-analiz\u0103 actualizat\u0103 - Centrul de Instruire \u00een Domeniul S\u0103n\u0103t\u0103\u0163ii Reproductive\" \/>\n<meta property=\"og:description\" content=\"The evidence establishing the high effectiveness and safety of a regimen combining mifepristone and misoprostol for first-trimester medication abortion is extensive and robust and the use of these two medicines for this purpose has expanded greatly over the past few decades. However, for many people seeking abortion, mifepristone is not always available or accessible. 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wp-image-7846\" \/>\u0414\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430, \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0449\u0438\u0435 \u0432\u044b\u0441\u043e\u043a\u0443\u044e \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0441\u0445\u0435\u043c\u044b, \u0441\u043e\u0447\u0435\u0442\u0430\u044e\u0449\u0435\u0439 \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b, \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430 \u0432 \u043f\u0435\u0440\u0432\u043e\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438, \u043e\u0431\u0448\u0438\u0440\u043d\u044b \u0438 \u0443\u0431\u0435\u0434\u0438\u0442\u0435\u043b\u044c\u043d\u044b, \u0438 \u0437\u0430 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0435 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u0434\u0435\u0441\u044f\u0442\u0438\u043b\u0435\u0442\u0438\u0439 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u044d\u0442\u0438\u0445 \u0434\u0432\u0443\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0434\u043b\u044f \u044d\u0442\u0438\u0445 \u0446\u0435\u043b\u0435\u0439 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0440\u0430\u0441\u0448\u0438\u0440\u0438\u043b\u043e\u0441\u044c. \u041e\u0434\u043d\u0430\u043a\u043e \u0434\u043b\u044f \u043c\u043d\u043e\u0433\u0438\u0445 \u043b\u044e\u0434\u0435\u0439, \u0436\u0435\u043b\u0430\u044e\u0449\u0438\u0445 \u043f\u0440\u0435\u0440\u0432\u0430\u0442\u044c \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c, \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d \u043d\u0435 \u0432\u0441\u0435\u0433\u0434\u0430 \u0434\u043e\u0441\u0442\u0443\u043f\u0435\u043d. \u0412 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0443\u0435\u0442\u0441\u044f \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u0442\u044c \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b.\n\n\u041e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u044f Gynuity Health Projects \u043f\u0440\u043e\u0432\u0435\u043b\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043e\u0431\u0437\u043e\u0440 \u0438 \u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0437 \u0438\u043c\u0435\u044e\u0449\u0438\u0445\u0441\u044f \u0434\u0430\u043d\u043d\u044b\u0445 \u043f\u043e \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430 \u0432 \u043f\u0435\u0440\u0432\u044b\u0435 12 \u043d\u0435\u0434\u0435\u043b\u044c \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438. \u042d\u0442\u043e \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0435\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u043e\u0431\u043d\u043e\u0432\u043b\u044f\u0435\u0442 \u043d\u0430\u0448 <span><a href=\"https:\/\/gynuity.org\/resources\/efficacy-of-misoprostol-alone-for-first-trimester-medical-abortion-a-systematic-review\">\u043f\u0440\u0435\u0434\u044b\u0434\u0443\u0449\u0438\u0439 \u043e\u0431\u0437\u043e\u0440<\/a><\/span>, \u043e\u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u0432 2019 \u0433\u043e\u0434\u0443.\n\n<strong>\u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u0438\u0442\u043e\u0433\u0438<\/strong>\n\n- \u0411\u044b\u043b\u0438 \u0441\u043e\u0431\u0440\u0430\u043d\u044b \u0438 \u043f\u0440\u043e\u0430\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u0434\u0430\u043d\u043d\u044b\u0435 \u0438\u0437 49 \u043e\u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0440\u0430\u0431\u043e\u0442. \u0412\u0441\u0435\u0433\u043e \u0431\u044b\u043b\u043e \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043e 66 \u0433\u0440\u0443\u043f\u043f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0448\u0438\u0445 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0435 \u0441\u0445\u0435\u043c\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u043e\u043c.\n\n- \u0418\u0441\u0445\u043e\u0434\u044b \u0430\u0431\u043e\u0440\u0442\u043e\u0432 \u0431\u044b\u043b\u0438 \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u044b \u0443 16 354 \u0447\u0435\u043b\u043e\u0432\u0435\u043a - 93% \u043e\u0442 \u043e\u0431\u0449\u0435\u0433\u043e \u0447\u0438\u0441\u043b\u0430 \u043f\u0440\u043e\u0448\u0435\u0434\u0448\u0438\u0445 \u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0443 \u043b\u0435\u0447\u0435\u043d\u0438\u044f.\n\n- \u0412 \u0446\u0435\u043b\u043e\u043c, 2 960 \u0447\u0435\u043b\u043e\u0432\u0435\u043a \u0441\u0442\u043e\u043b\u043a\u043d\u0443\u043b\u0438\u0441\u044c \u0441 \u043d\u0435\u0443\u0434\u0430\u0447\u0435\u0439 \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 (\u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430: 15%).\n\n- \u041e\u043a\u043e\u043b\u043e 521 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u044e\u0449\u0438\u0445\u0441\u044f \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0435\u0439 \u0431\u044b\u043b\u043e \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043e \u0443 9228 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a, \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u043e \u044d\u0442\u043e\u043c\u0443 \u043f\u043e\u0432\u043e\u0434\u0443 (\u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430: 6%).\n\n- \u0421\u0440\u0435\u0434\u0438 11 007 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u043a, \u043a\u043e\u0442\u043e\u0440\u044b\u043c \u0431\u044b\u043b\u043e \u0440\u0430\u0437\u0440\u0435\u0448\u0435\u043d\u043e \u043f\u0440\u0438\u043d\u044f\u0442\u044c \u043d\u0435 \u043c\u0435\u043d\u0435\u0435 \u0442\u0440\u0435\u0445 \u0434\u043e\u0437 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430, \u043f\u0435\u0440\u0432\u0430\u044f \u0438\u0437 \u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043b\u0430 \u0438\u0437 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 800 \u043c\u043a\u0433, \u0432\u0432\u0435\u0434\u0435\u043d\u043d\u043e\u0433\u043e \u0432\u0430\u0433\u0438\u043d\u0430\u043b\u044c\u043d\u043e, \u0441\u0443\u0431\u043b\u0438\u043d\u0433\u0432\u0430\u043b\u044c\u043d\u043e \u0438\u043b\u0438 \u0431\u0443\u043a\u043a\u0430\u043b\u044c\u043d\u043e, \u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430 \u0440\u0438\u0441\u043a\u0430 \u043d\u0435\u0443\u0434\u0430\u0447\u0438 \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u0430 11%.\n\n- \u041e\u0447\u0435\u043d\u044c \u043c\u0430\u043b\u043e \u043b\u044e\u0434\u0435\u0439 \u0431\u044b\u043b\u0438 \u0433\u043e\u0441\u043f\u0438\u0442\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u044b \u043f\u043e \u043f\u0440\u0438\u0447\u0438\u043d\u0430\u043c, \u0441\u0432\u044f\u0437\u0430\u043d\u043d\u044b\u043c \u0441 \u0430\u0431\u043e\u0440\u0442\u043e\u043c, \u0438\u043b\u0438 \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0438 \u043f\u0435\u0440\u0435\u043b\u0438\u0432\u0430\u043d\u0438\u0435 \u043a\u0440\u043e\u0432\u0438 - \u043d\u0435 \u0431\u043e\u043b\u0435\u0435 0,2% \u043e\u0442 15 679 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u043f\u043e\u0434\u043b\u0435\u0436\u0430\u0449\u0438\u0445 \u0430\u043d\u0430\u043b\u0438\u0437\u0443.\n\n\u042d\u0442\u043e\u0442 \u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u044b\u0439 \u043e\u0431\u0437\u043e\u0440 \u0438 \u0430\u043d\u0430\u043b\u0438\u0437 \u043f\u043e\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442, \u0447\u0442\u043e \u0443 \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0430 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0430\u0431\u043e\u0440\u0442 \u0431\u044b\u043b \u043f\u043e\u043b\u043d\u043e\u0441\u0442\u044c\u044e \u0437\u0430\u0432\u0435\u0440\u0448\u0435\u043d \u0431\u0435\u0437 \u043f\u0440\u043e\u0446\u0435\u0434\u0443\u0440\u044b \u0438\u043b\u0438 \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0432\u043c\u0435\u0448\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u043f\u043e\u043c\u0438\u043c\u043e 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\u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430 \u043d\u0430 \u0440\u0430\u043d\u043d\u0438\u0445 \u0441\u0440\u043e\u043a\u0430\u0445 \u0438 \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0440\u0430\u0437\u0443\u043c\u043d\u043e\u0439 \u0430\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u043e\u0439, \u0435\u0441\u043b\u0438 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u0435 \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u043d\u0435 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u044b\u043c.\n<ol>\n \t<li>\u0420\u044d\u0439\u043c\u043e\u043d\u0434 \u0438 \u0434\u0440., <span><a href=\"https:\/\/gynuity.org\/resources\/effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">\u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0442\u043e\u043b\u044c\u043a\u043e \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430 \u0432 \u043f\u0435\u0440\u0432\u043e\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435 \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u0438: \u041e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u044b\u0439 \u0421\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u041e\u0431\u0437\u043e\u0440 \u0438 \u041c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0437, \u041a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0446\u0438\u044f<\/a><\/span>.<\/li>\n<\/ol>\n\u0418\u0434\u0435\u043d\u0442\u0438\u0444\u0438\u043a\u0430\u0442\u043e\u0440 \u0446\u0438\u0444\u0440\u043e\u0432\u043e\u0433\u043e \u043e\u0431\u044a\u0435\u043a\u0442\u0430:<span><a href=\"https:\/\/www.contraceptionjournal.org\/article\/S0010-7824(23)00226-3\/fulltext\">10.1016\/j.contraception.2023.110132<\/a><\/span>\n\n<strong>\u041f\u0440\u0438\u043c\u0435\u0447\u0430\u043d\u0438\u0435<\/strong>\n\n\u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u044b\u0439 \u0430\u0431\u043e\u0440\u0442 \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0430 \u0438 \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0438\u043c\u0435\u0435\u0442 \u043d\u0435\u043e\u0441\u043f\u043e\u0440\u0438\u043c\u044b\u0435 \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0430 \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0438 \u043e\u0431\u0449\u0435\u043f\u0440\u0438\u0437\u043d\u0430\u043d\u043d\u043e \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0431\u043e\u043b\u0435\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u043c. \u041f\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u0435\u044f\u0442\u0435\u043b\u0438 \u0434\u043e\u043b\u0436\u043d\u044b \u0432\u044b\u0441\u0442\u0443\u043f\u0430\u0442\u044c \u0437\u0430 \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u0434\u043e\u0441\u0442\u0443\u043f\u0430 \u043a \u043c\u0438\u0444\u0435\u043f\u0440\u0438\u0441\u0442\u043e\u043d\u0443.\n\n<span><a href=\"https:\/\/gynuity.org\/resources\/research-summary-effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a: \u0421\u0441\u044b\u043b\u043a\u0430<\/a><\/span>\n\n[:]\n\n","_ru_post_excerpt":"","_ru_post_title":"\u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0442\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0437\u043e\u043f\u0440\u043e\u0441\u0442\u043e\u043b\u0430 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u043e\u0433\u043e \u0430\u0431\u043e\u0440\u0442\u0430 \u0432 \u043f\u0435\u0440\u0432\u043e\u043c \u0442\u0440\u0438\u043c\u0435\u0441\u0442\u0440\u0435: \u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u044b\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043e\u0431\u0437\u043e\u0440 \u0438 \u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0437","_ru_post_name":"eficacitatea-si-siguranta-utilizarii-doar-a-misoprostolului-pentru-avortul-medical-din-primul-trimestru-o-revizuire-sistematica-si-o-meta-analiza-actualizata","_ro_post_content":"\n\n<img src=\"https:\/\/cidsr.md\/wp-content\/uploads\/2023\/09\/woman-pill-1024x683.jpg\" alt=\"\" width=\"900\" height=\"600\" class=\"aligncenter size-large wp-image-7846\" \/>Dovezile care sus\u021bin eficacitatea \u0219i siguran\u021ba ridicat\u0103 a unui tratament care combin\u0103 mifepristonul \u0219i misoprostolul pentru avortul medicamentos \u00een primul trimestru de sarcin\u0103 sunt numeroase \u0219i conving\u0103toare, iar utilizarea acestor dou\u0103 medicamente \u00een acest scop s-a extins semnificativ \u00een ultimele c\u00e2teva decenii. Cu toate acestea, pentru multe persoane care doresc s\u0103 \u00eentrerup\u0103 o sarcin\u0103, mifepristonul nu este u\u0219or de ob\u021binut. \u00cen absen\u021ba mifepristonului, se recomand\u0103 doar misoprostolul.\n\nGynuity Health Projects a efectuat o revizuire sistemic\u0103 \u0219i o meta-analiz\u0103 a dovezilor disponibile cu privire la eficacitatea \u0219i siguran\u021ba utiliz\u0103rii doar a misoprostolului pentru avortul medicamentos \u00een primele 12 s\u0103pt\u0103m\u00e2ni de sarcin\u0103. Acest ultim studiu actualizeaz\u0103 <span><a href=\"https:\/\/gynuity.org\/resources\/efficacy-of-misoprostol-alone-for-first-trimester-medical-abortion-a-systematic-review\">analiza realizat\u0103 anterior<\/a><\/span> \u0219i publicat\u0103 \u00een 2019.\n\n<strong>Principalele constat\u0103ri<\/strong>\n<ul>\n \t<li>Au fost colectate \u0219i analizate date din 49 de lucr\u0103ri publicate. \u00cen total, au fost \u00eenregistrate 66 de grupuri de pacien\u021bi,care au primit diferite scheme de tratament doar cu misoprostol.<\/li>\n \t<li>Rezultatele avorturilor au fost stabilite la 16 354 de persoane - 93% dintre cele care au urmat programul de tratament.<\/li>\n \t<li>\u00cen total, 2.960 de persoane au suferit un e\u0219ec al tratamentului (estimare meta-analitic\u0103: 15%).<\/li>\n \t<li>Aproximativ 521 de sarcini remanente au fost raportate la 9228 de paciente examinate cu privire la acest tratament (estimare meta-analitic\u0103: 6%).<\/li>\n \t<li>Dintre cele 11.007 paciente c\u0103rora li s-a permis s\u0103 primeasc\u0103 cel pu\u021bin trei doze de misoprostol, dintre care prima a constat \u00een 800 mcg de misoprostol administrat pe cale vaginal\u0103, sublingual\u0103 sau bucal\u0103, estimarea meta-analitic\u0103 a riscului de e\u0219ec a fost de 11%.<\/li>\n \t<li>Foarte pu\u021bine persoane au fost spitalizate din motive legate de avort sau au primit transfuzii de s\u00e2nge - nu mai mult de 0,2% din cele 15.679 de paciente care au fost examinate.<\/li>\n<\/ul>\nAceast\u0103 evaluare \u0219i analiz\u0103 actualizat\u0103 arat\u0103 c\u0103, la majoritatea pacientelor, avortul a fost complet finalizat f\u0103r\u0103 o procedur\u0103 sau interven\u021bie medical\u0103, \u00een afar\u0103 de regimul planificat de misoprostol. Se confirm\u0103 \u00een continuare principala constatare a studiului nostru anterior, conform c\u0103reia misoprostolul este eficient \u0219i sigur pentru avortul medicamentos timpuriu \u0219i reprezint\u0103 o alternativ\u0103 rezonabil\u0103 \u00een cazul \u00een care mifepristona nu este disponibil\u0103.\n<ol>\n \t<li>Raymond \u0219i colab.,<a href=\"https:\/\/gynuity.org\/resources\/effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Eficacitatea \u0219i siguran\u021ba utiliz\u0103rii doar a misoprostolului pentru avortul medicamentos din primul trimestru: O Revizuire Sistematic\u0103 \u0219i Meta-analiz\u0103 actualizat\u0103, Contracep\u021bie.<\/a><\/li>\n<\/ol>\nIdentificatorul obiectului digital:<span><a href=\"https:\/\/www.contraceptionjournal.org\/article\/S0010-7824(23)00226-3\/fulltext\">10.1016\/j.contraception.2023.110132<\/a><\/span>\n\n<strong>Not\u0103 <\/strong>\n\nAvortul medicamentos cu mifepriston \u0219i misoprostol prezint\u0103 avantaje incontestabile fa\u021b\u0103 de utilizarea doar a misoprostolului \u0219i este recunoscut pe scar\u0103 larg\u0103 ca fiind o metod\u0103 mai eficient\u0103. Factorii de decizie politic\u0103 ar trebui s\u0103 pledeze pentru cre\u0219terea accesului la mifepriston\u0103.\n\n<span><a href=\"https:\/\/gynuity.org\/resources\/research-summary-effectiveness-and-safety-of-misoprostol-only-for-first-trimester-medication-abortion-an-updated-systematic-review-and-meta-analysis\">Sursa:LINK<\/a><\/span>\n\n\n\n","_ro_post_excerpt":"","_ro_post_title":"Eficacitatea \u0219i siguran\u021ba utiliz\u0103rii doar a misoprostolului pentru avortul medical din primul trimestru: o revizuire sistematic\u0103 \u0219i o meta-analiz\u0103 actualizat\u0103","_ro_post_name":"eficacitatea-si-siguranta-utilizarii-doar-a-misoprostolului-pentru-avortul-medical-din-primul-trimestru-o-revizuire-sistematica-si-o-meta-analiza-actualizata","edit_language":"en"},"_links":{"self":[{"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/news\/10715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/types\/news"}],"author":[{"embeddable":true,"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/users\/4"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cidsr.md\/en\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/media?parent=10715"}],"wp:term":[{"taxonomy":"blog_news","embeddable":true,"href":"https:\/\/cidsr.md\/en\/wp-json\/wp\/v2\/blog_news?post=10715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}